The Complex of Ciliary Neurotrophic Factor-Ciliary Neurotrophic Factor Receptor α Up-Regulates Connexin43 and Intercellular Coupling in Astrocytes via the Janus Tyrosine Kinase/Signal Transducer and Activator of Transcription Pathway
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منابع مشابه
The Complex of Ciliary Neurotrophic Factor-Ciliary Neurotrophic Factor Receptor Up-Regulates Connexin43 and Intercellular Coupling in Astrocytes via the Janus Tyrosine Kinase/Signal Transducer and Activator of Transcription Pathway□D
*Department of Anatomy and Cell Biology, The University of British Columbia, Vancouver, British Columbia, Canada; †Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario V6T 1Z3, Canada; and ‡Laboratory of Developmental Biology, National Heart, Lung and Blood Institute, Natio...
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Objective(s): Occlusal trauma is one of the most common forms of oral biting dysfunction. Long-term occlusal trauma could weaken the stomatognathic system; especially damage one’s masticatory muscle. Through using the rat model, this study investigated the trophic effect of ciliary neurotrophic factor (CNTF) on injured masseter muscle. Materials and Methods: Male Wistar rats (n=36) were random...
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Ciliary neurotrophic factor (Cntf) plays an essential role in postnatal maintenance of spinal motoneurons. Whereas the expression of this neurotrophic factor is low during embryonic development, it is highly up-regulated after birth in myelinating Schwann cells of rodents. To characterize the underlying transcriptional mechanisms, we have analyzed and compared the effects of various glial trans...
متن کاملCloning, Mapping, and Retinal Expression of the Canine Ciliary Neurotrophic Factor Receptor α (CNTFRα)
METHODS. The complete coding sequence of the canine CNTFR cDNA was cloned, and radiation hybrid (RH) mapping was used to determine the chromosomal localization of the gene. CNTFR mRNA expression in retina and other tissues was examined by reverse transcription–polymerase chain reaction. The cellular distribution of CNTFR in the canine retina was studied by in situ hybridization and immunocytoch...
متن کاملThe protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression
Ciliary neurotrophic factor, along with other neuropoietic cytokines, signals through the shared receptor subunit gp130 [1-3], leading to the tyrosine phosphorylation of a number of substrates [4,5], including the transcription factors STAT1 and STAT3 and the protein tyrosine phosphatase SHP-2 [6,7] [8]. SHP-2 (also known as PTP1D, SHPTP2, Syp and PTP2C) is a positive regulatory molecule requir...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2004
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e04-03-0271